Overview
SCIENTIFIC SCORE
Questionable
Based on 35 Researches
6.4
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Vitamin D (as ergocalciferol)
10 mcg (400 I.U.)
50%
Calcium (as calcium hydroxyapatite, calcium citrate, calcium aspartate)†
1,000 mg
77%
Phosphorus (as calcium hydroxyapatite)†
500 mg
40%
Magnesium (as magnesium oxide, magnesium aspartate, magnesium citrate, magnesium taurinate)†
500 mg
119%
Top Medical Research Studies
9
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Read More
8
We examined whether serum magnesium levels at admission could predict in-hospital outcomes for patients experiencing a heart attack.
In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.
Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.
In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.
Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.
Read More
5
OCT and angiography show comparable effectiveness
We examined how two guidance methods—optical coherence tomography (OCT) and angiography—perform during magnesium bioresorbable scaffold (MBRS) implantation in patients recovering from a non-ST-elevation heart attack.
With 75 participants, our study revealed that both techniques resulted in comparable healing patterns after six months. Though OCT-guided intervention showed slightly better outcomes in certain technical measures, neither approach demonstrated a significant advantage in overall heart healing.
Thus, for NSTEMI patients, choosing between OCT and angiography for MBRS placement may depend on other factors, as both methods appear effective.
With 75 participants, our study revealed that both techniques resulted in comparable healing patterns after six months. Though OCT-guided intervention showed slightly better outcomes in certain technical measures, neither approach demonstrated a significant advantage in overall heart healing.
Thus, for NSTEMI patients, choosing between OCT and angiography for MBRS placement may depend on other factors, as both methods appear effective.
Read More
Most Useful Reviews
7
Supports muscle function
Promotes calcium absorption, maintaining normal development and health of bones and teeth, and supporting normal contraction and nerve sensitivity of muscles and the heart.
Read More
6
Strengthens heart
Good quality, beneficial for the heart and muscles, strengthens bones and enhances the overall condition of the nervous system.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 35 Researches
6.4
- All Researches
9
Vitamin D and activity improve survival
We examined how vitamin D status and physical activity (PA) relate to long-term survival following a heart attack, also known as a myocardial infarction (MI). In our analysis of 4,837 MI patients, we measured the levels of vitamin D in their blood and assessed their physical activity using a reliable questionnaire.
Over an average follow-up of 14.4 years, we observed that higher vitamin D levels were linked to a significant reduction in both cardiovascular (CVD) and all-cause mortality. Specifically, patients with adequate vitamin D levels had about 37% lower risk of CVD-related deaths compared to those with lower levels. Additionally, engaging in more physical activity also correlated with a lower mortality risk.
Importantly, we found that those with low vitamin D levels and little to no physical activity faced a threefold increased risk of mortality compared to patients who had high vitamin D levels and were active. These findings suggest that both vitamin D and physical activity independently contribute to improving survival rates post-heart attack, regardless of other health factors.
Overall, this study underscores the importance of monitoring vitamin D levels and encouraging physical activity to enhance recovery and longevity after a heart attack.
Over an average follow-up of 14.4 years, we observed that higher vitamin D levels were linked to a significant reduction in both cardiovascular (CVD) and all-cause mortality. Specifically, patients with adequate vitamin D levels had about 37% lower risk of CVD-related deaths compared to those with lower levels. Additionally, engaging in more physical activity also correlated with a lower mortality risk.
Importantly, we found that those with low vitamin D levels and little to no physical activity faced a threefold increased risk of mortality compared to patients who had high vitamin D levels and were active. These findings suggest that both vitamin D and physical activity independently contribute to improving survival rates post-heart attack, regardless of other health factors.
Overall, this study underscores the importance of monitoring vitamin D levels and encouraging physical activity to enhance recovery and longevity after a heart attack.
Read More
9
We explored how calcium signaling influences heart cell proliferation, particularly after injuries like heart attacks. Our study centered on the L-Type Calcium Channel (LTCC) and how its inhibition might help heart cells regenerate. Remarkably, when we inhibited LTCC—either through pharmacological means or by enhancing the activity of an inherent inhibitor called RRAD—we observed significant boosts in heart cell activity.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
Read More
9
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Read More
9
Magnesium scaffolds improve heart attack outcomes
We examined the performance of two types of bioresorbable scaffolds in patients experiencing acute coronary syndrome (ACS) - a common and serious manifestation of heart disease. Specifically, we compared the effectiveness of magnesium-based scaffolds, known as Magmaris, with the earlier polymer scaffolds called Absorb.
Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.
Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.
Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.
Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.
Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
Read More
8
We conducted a study to understand how vitamin D could impact lung injuries resulting from a heart attack, specifically myocardial infarction. The research involved six groups of experimental animals to investigate different treatment approaches. Among these groups were those receiving only vitamin D, those treated with nerolidol, and those experiencing myocardial infarction without any treatment.
Our findings indicated that serious lung injuries indeed occurred due to myocardial infarction. Notably, treatments with vitamin D showed a potential curative effect on these injuries. We also explored the role of two proteins, asprosin and spexin, which appeared to be linked to both the damages and the recovery processes within the lungs.
Interestingly, it seemed that vitamin D's effectiveness depended on the expression of asprosin and spexin, while nerolidol could operate through a different mechanism that may not rely on these proteins. These insights into how vitamin D and nerolidol can mitigate the effects of heart attacks open avenues for further exploration in treatment.
Our findings indicated that serious lung injuries indeed occurred due to myocardial infarction. Notably, treatments with vitamin D showed a potential curative effect on these injuries. We also explored the role of two proteins, asprosin and spexin, which appeared to be linked to both the damages and the recovery processes within the lungs.
Interestingly, it seemed that vitamin D's effectiveness depended on the expression of asprosin and spexin, while nerolidol could operate through a different mechanism that may not rely on these proteins. These insights into how vitamin D and nerolidol can mitigate the effects of heart attacks open avenues for further exploration in treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7
Supports muscle function
Promotes calcium absorption, maintaining normal development and health of bones and teeth, and supporting normal contraction and nerve sensitivity of muscles and the heart.
Read More
6
Strengthens heart
Good quality, beneficial for the heart and muscles, strengthens bones and enhances the overall condition of the nervous system.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Balasubramanian A, Kunchala K, Shahbaz A, Kar A, Sankar J, et al. Association of Vitamin D Deficiency as an Independent Risk Factor for Myocardial Infarction and Its Therapeutic Implications: A Systematic Review. Cureus. 2025;17:e77375. doi:10.7759/cureus.77375
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01681-x
- Olędzki S, Siennicka A, Maciejewska-Markiewicz D, Stachowska E, Jakubiak N, et al. Calcitriol Concentration in the Early Phase of Myocardial Infarction and Its Relation to Left Ventricular Ejection Fraction. Metabolites. 2024;14. doi:10.3390/metabo14120686
- Cruijsen E, van Pijkeren CS, Evers I, Visseren FLJ, Geleijnse JM. Vitamin D status, physical activity and long-term mortality risk after myocardial infarction: a prospective analysis in the Alpha Omega Cohort. Eur J Prev Cardiol. 2024. doi:10.1093/eurjpc/zwae359
- Chin WC, Huang YS, Wu LS, Lee KT, Ho CT, et al. The Prognosis of Patients with Myocardial Infarction after Light Therapy: A Preliminary Study. Biomed J. 2024. doi:10.1016/j.bj.2024.100783
- Kocaman N. Evaluating the therapeutic effect of vitamin D and nerolidol on lung injury due to experimental myocardial infarction: The potential role of asprosin and spexin. Tissue Cell. 2024;89:102444. doi:10.1016/j.tice.2024.102444
- Gaggini M, Marchi F, Pylypiv N, Parlanti A, Storti S, et al. Vitamin D and Ceramide Metabolomic Profile in Acute Myocardial Infarction. Metabolites. 2024;14. doi:10.3390/metabo14040233
- Zhao S, Chen X, Wan Z, Geng T, Lu Q, et al. Associations of serum 25-hydroxyvitamin D and vitamin D receptor polymorphisms with risks of cardiovascular disease and mortality among patients with chronic kidney disease: a prospective study. Am J Clin Nutr. 2024;119:1397. doi:10.1016/j.ajcnut.2024.04.001
- Yaman AE, Ceylan US. Effects of Vitamin D Levels on Long-Term Coronary Events in Patients with Proven Coronary Artery Disease: Six-Year Follow-Up. J Clin Med. 2023;12. doi:10.3390/jcm12216835
- Thompson B, Waterhouse M, English DR, McLeod DS, Armstrong BK, et al. Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial. BMJ. 2023;381:e075230. doi:10.1136/bmj-2023-075230
- Lin X, Chen X, Liu S, Deng Y, Wang Y, et al. Associations of Serum 25(OH)D With Risk of Recurrent Cardiovascular Events in Individuals With Coronary Heart Disease. J Clin Endocrinol Metab. 2023;108:e1712. doi:10.1210/clinem/dgad339
- Devilée LAC, Salama ABM, Miller JM, Reid JD, Ou Q, et al. Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity. NPJ Regen Med. 2025;10:1. doi:10.1038/s41536-025-00389-z
- Demirtola Aİ, Mammadli A, Çiçek G. The Role of Magnesium Levels in the Progression of Contrast-Induced Nephropathy in Patients With STEMI Undergoing Primary PCI. Angiology. 2025. doi:10.1177/00033197251314629
- Jin Y, Lin Q, Wang D, Gong M, Huang W, et al. Hypomagnesemia is a Risk Factor for Acute Kidney Injury in Patients Admitted With ST-Segment Elevation Myocardial Infarction: A Retrospective Observational Study. J Ren Nutr. 2024. doi:10.1053/j.jrn.2024.12.006
- Naveen V, Rajesh Lenin R, Stanley LM, Kumar JS. Serum Magnesium Levels and QTc Interval Prolongation As Prognostic Markers in Acute Myocardial Infarction: A Randomized Controlled Study. Cureus. 2024;16:e66051. doi:10.7759/cureus.66051
- Zhuang J, Zhang Q, Wang H, Su PH, Chen PY. Association between short-term changes in serum magnesium and in-hospital mortality following acute myocardial infarction: a cohort study based on the MIMIC database. Magnes Res. 2024;37:45. doi:10.1684/mrh.2024.0517
- Zhang J, Sun D, Guo Y, Tong J, Liu Q, et al. Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair. J Nanobiotechnology. 2024;22:433. doi:10.1186/s12951-024-02685-0
- Wang B, Pan S, Nie C, Zou R, Liu J, et al. Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats. Sci Rep. 2024;14:10959. doi:10.1038/s41598-024-60609-2
- Fan C, Qin K, Iroegbu CD, Xiang K, Gong Y, et al. Magnesium lithospermate B enhances the potential of human-induced pluripotent stem cell-derived cardiomyocytes for myocardial repair. Chin Med J (Engl). 2024;137:1857. doi:10.1097/CM9.0000000000002867
- Segev A, Shechter M, Tsur AM, Belkin D, Cohen H, et al. Serum Magnesium Is Associated with Long-Term Survival of Non-ST-Elevation Myocardial Infarction Patients. Nutrients. 2023;15. doi:10.3390/nu15194299
- Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. doi:10.1177/14791641231188705
- Sabah Z, Wani J, Deajim M, Al Zomia AS, Asiri A, et al. Serum Magnesium in Patients With Acute Myocardial Infarction and Its Effect on Cardiac Complications and Mortality in Myocardial Infarction Patients. Cureus. 2023;15:e38147. doi:10.7759/cureus.38147
- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. doi:10.1016/j.jacc.2022.09.048
- Evers I, Cruijsen E, Kornaat I, Winkels RM, Busstra MC, et al. Dietary magnesium and risk of cardiovascular and all-cause mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort. Front Cardiovasc Med. 2022;9:936772. doi:10.3389/fcvm.2022.936772
- Rola P, Włodarczak A, Łanocha M, Barycki M, Szudrowicz M, et al. Outcomes of the two generations of bioresorbable scaffolds (Magmaris vs. Absorb) in acute coronary syndrome in routine clinical practice. Cardiol J. 2022;30:870. doi:10.5603/CJ.a2022.0047
- Ortega-Paz L, Brugaletta S, Gomez-Lara J, Alfonso F, Cequier A, et al. Magnesium-based resorbable scaffold vs permanent metallic sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction: 3-year results of the MAGSTEMI randomised controlled trial. EuroIntervention. 2022;18:e389. doi:10.4244/EIJ-D-21-00651
- Hasan MZ, Nahar K, Sharif JU, Paul SC, Thakur AK, et al. Serum Magnesium Level and It's Relation in Predicting Adverse In-Hospital Outcome in Patients with First Attack of Myocardial Infarction. Mymensingh Med J. 2023;32:65.
- Fallesen CO, Antonsen L, Maehara A, Noori M, Hougaard M, et al. Optical Coherence Tomography- Versus Angiography-Guided Magnesium Bioresorbable Scaffold Implantation in NSTEMI Patients. Cardiovasc Revasc Med. 2022;40:101. doi:10.1016/j.carrev.2021.12.003
- Włodarczak A, Łanocha M, Lesiak M, Benett J, Szudrowicz M, et al. Long-term clinical follow-up of the resorbable magnesium scaffolds in acute coronary syndrome patients. Kardiol Pol. 2021;79:827. doi:10.33963/KP.a2021.0035
- Açıkgöz E, Açıkgöz SK, Çiçek G. Serum magnesium concentration may predict no-reflow phenomenon in primary angioplasty for ST-elevation myocardial infarction. Magnes Res. 2020;33:123. doi:10.1684/mrh.2021.0477
- Shlezinger M, Amitai Y, Goldenberg I, Atar S, Shechter M. Acute myocardial infarction severity, complications, and mortality associated with lack of magnesium intake through consumption of desalinated seawater. Magnes Res. 2019;32:39. doi:10.1684/mrh.2019.0449
- Sabaté M, Alfonso F, Cequier A, Romaní S, Bordes P, et al. Magnesium-Based Resorbable Scaffold Versus Permanent Metallic Sirolimus-Eluting Stent in Patients With ST-Segment Elevation Myocardial Infarction: The MAGSTEMI Randomized Clinical Trial. Circulation. 2019;140:1904. doi:10.1161/CIRCULATIONAHA.119.043467
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- Lee TM, Chang NC, Lin SZ. Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium. PLoS One. 2018;13:e0202979. doi:10.1371/journal.pone.0202979
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